IMPROVEMENTS TO DNA DAMAGE WITH CANCER CELLS GENE VARIATION
Recent study mentions that certain variations of a gene can repair DNA damage in cancer. These findings also are published in the journal Ethical Digest June 2009. The study recommends, the discovery of this gene should be studied further in order to eventually understand more about the benefits.
The work done to prevent the accumulation of genetic damage that is not soon become cancer is the balancing of protein in the DNA. The researchers found in the general population there is variance in the gene that could encode proteins that can repair DNA. Other studies also mention the relationship between the decline in DNA repair in sensitivity to certain types of cancer including breast cancer, colon and lung.
Dr. Randa El-Zain and his team conduct research at the University of Texas to determine the role of genetic variants or polymorphisms in DNA repair genes in cancer, they evaluate the relationship between polymorphisms in five DNA repair genes XPC namely cancer, XPD, XPG, XRCC1 and gene XRCC3, with a population sample of 420 of 200 people with Hodgkin’s lymphoma (which preceded the spread of disease from lymph node to other organs) and 220 healthy samples.
To five of these genes using a different track in achieving its objectives, namely repair of DNA damage in cancer, but all the ways in which these genes is to make different modifications of DNA damaged cancer, so that changes in these genes will be able to alter the shape and structure of proteins in charge of running the repair process.
Therefore this gene may also affect the amount of DNA in cancer undergoing repairs. Results obtained from this research is the variation of the five genes XPC, XPD, XPG, XRCC1 and XRCC3 genes capable of repairing damage to the cancer and thus may reduce the severity of the disease with its cancer or other words to reduce the growth of cancer cells.
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